Sarah Miriam Peale (May 19, 1800-February 4, 1885) was an American portrait painter, considered the first American woman to succeed as a professional artist.
Biography on Wikipedia: https://en.wikipedia.org/wiki/Sarah_Miriam_Peale

Portrait of the Honorable Dixon Hall Lewis by Sarah Miriam Peale
c.1842 / Oil on canvas / Size? / Birmingham Museum of Art, AL

Sarah Miriam Peale on Artnet: http://www.artnet.com/artists/sarah-miriam-peale/

Further reading:
https://nmwa.org/art/artists/sarah-miriam-peale/
https://www.newspapers.com/clip/23428892/lengthy-article-detailing-the-life-of/
https://nbmaa.wordpress.com/2010/11/16/a-dynasty-of-artists-the-peale-family/

Painter Cecilia Beaux (May 1, 1855-September 17, 1942) “successfully negotiated the gender separatism of the late nineteenth century while she gained international renown, allowing her to become the first full-time woman instructor at the Pennsylvania Academy of the Fine Arts.”
Biography on the Encyclopedia of Greater Philadelphia:
https://philadelphiaencyclopedia.org/archive/art-of-cecilia-beaux/

Mother and Daughter by Cecilia Beaux
1898 / Oil on canvas / 83″x44″ / Pennsylvania Academy of the Fine Arts, Philadelphia, PA

Cecilia Beaux on Artnet: http://www.artnet.com/artists/cecilia-beaux/

Further reading:
https://nmwa.org/art/artists/cecilia-beaux/
https://americanart.si.edu/artist/cecilia-beaux-300
https://en.wikipedia.org/wiki/Cecilia_Beaux